Fc gamma receptor polymorphisms in systemic lupus erythematosus and their correlation with the clinical severity of the disease.

F/F homozygotes had the highest risk of renal disease as compared with V/V homozygous.[ 2 , 3 , 12 ] A single nucleotide polymorphism in Fc γ RII B (695 T> C), coding for nonsynonymous substitution Ile232Thr (I232T), within the transmembrane domain in Japanese patients revealed that the frequency of the 232T/T genotype was significantly increased in patients with SLE.[ 12 ] The association of Fc γ RII B polymorphism with susceptibility to SLE in Chinese patients revealed a highly significant and independent association for Fc γ RII B and Fc γ RIII A genotypes where Fc γ RII A-H 131R and Ile 232 Thr (I232T) of Fc γ RII B and Fc γ RIII A-176V polymorphisms were found to be associated with lupus nephritis; these results suggested that Fc γ RII B is a common susceptibility factor to SLE ne

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