Synaptic plasticity in the hippocampus of a APP/PS1 mouse model of Alzheimer's disease is impaired in old but not young mice.

APPPS1-21 animals showed impaired PPF compared with littermate controls at 80 ms and 160 ms interstimulus interval as shown in post-hoc tests: At the interstimulus interval 80 ms, Yuen's test (t 6.17 = 3.696, p<0.01) showed a highly significant difference between genotypes, and at the interstimulus interval 160 ms Yuen's test (t 5.65 = 3.02, p<0.03) discovered a significant impairment of PPF in the APPPS1-21 mice as well ( fig. 9 ).

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