highly significantp <10 −6
Position-specific stability is correlated to a greater extent than is enthalpy or entropy Closer inspection of the correlation distributions suggested a second pattern: within homologous proteins, enthalpy and entropy generally did not exhibit correlations as great as those for stability (modes of 0.39, 0.50, and 0.61 respectively, Table 1 ; differences between these homolog distributions were all highly significant, exhibiting p <10 −6 as assessed by chi-square tests with 19 d.o.f ).