highly significantp= 8.5×10 −10
Meta-analysis of the stage 1 and 2 datasets also produced highly significant evidence of association (rs11136000: p= 8.5×10 −10 , OR = 0.861 and rs3851179: p= 1.3×10 −9 , OR= 0.859, two-tailed, Table 1 ) for CLU and PICALM loci respectively.