A combined phase I and II open label study on the effects of a seaweed extract nutrient complex on osteoarthritis.

There was a highly significant treatment by time interaction effect (likelihood ratio test, chi-square = 15.155, df = 2, P = 0.0005), which was largely located after day 21 as indicated by the tests of the interaction parameters in Table 3 .

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This hypothesis was confirmed at P < 0.05 for the average COAT (0.043) scale, and the physical difficulties (0.010) and overall symptoms (0.044) sub-scales, but failed to reach significance for the pain (0.088) and stiffness (0.089) subscales.

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