African ancestry allelic variation at the MYH9 gene contributes to increased susceptibility to non-diabetic end-stage kidney disease in Hispanic Americans.

In contrast to the global ancestry estimates noted above, these local ancestry estimates at the MYH9 locus, did show a significant association with non-diabetic ESKD status in the Hispanic American population ( P = 0.0002 for Welch's two-sample t -test, P = 0.0009 for Kolmogorov–Smirnov test) and marginally significant association in the African American population ( P = 0.02 for Welch's two-sample t -test, P = 0.06 for Kolmogorov–Smirnov test).

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A secondary analysis comparing ESKD diabetic patients to controls yielded no significant correlations: no P -value for any of the 42 SNPs was <0.01 before multiple comparisons correction and none of these could be considered significant under FDR or any other reasonable multiple comparison correction ( Supplementary Material, Table S4.6 ).

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