Risks of second primary cancer among patients with major histological types of lung cancers in both men and women.

In our study, the SIRs for smoking-related SPCs after a first primary SCC and SCLC did not change significantly across the calendar years, but we observed an increasing trend for overall smoking-related SPCs in male ADC patients ( P for trend=0.04), suggesting a time trend between tobacco smoking and a more important role in the development of ADC; this was not observed in female ADC cases ( P =0.74).

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