Long-term AZT exposure alters the metabolic capacity of cultured human lymphoblastoid cells.

Additionally, a comparison among the unexposed controls cultured in parallel for P 1 , P 4 , P 5 , and P 14 showed no statistical significance ( p = 0.084) In cells exposed to 800μM AZT at P 1 , P 4 , P 5 , and P 14 , the MN (per 1000 cells examined) reached values of 20, 61, 38, and 35, respectively, a significant increase for passage 1 ( p = 0.02) compared to the untreated control (P U ) and highly significant increase for P 4 ( p = 0.0001), P 5 ( p = 0.0002), and P 14 ( p = 0.0001); p < 0.05 for each passage compared to P U .

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Statistical Interpretation Application of linear regression to the mean levels of AZT-DNA incorporation at P 1 showed a positive trend with an R value of 0.737.

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