Time course and mechanisms of circulating progenitor cell reduction in the natural history of type 2 diabetes.

Given the large uncertainty of such a estimate, to select a limited number of unrelated highly significant variables, we applied a stepwise regression approach and repeated the analyses controlling only for this parsimonious set of variables (model 2).

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The trend of adjusted values confirms a first nadir of CD34+ cell count at diagnosis of type 2 diabetes (−33.8%, P = 0.01 in model 1; −31.7%, P = 0.01 in model 2) and a second nadir after ≥20 years of disease duration but was marginally significant (−39.7% in model 1; −34.9% in model 2).

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