Genetic and epigenetic tumor suppressor gene silencing are distinct molecular phenotypes driven by growth promoting mutations in nonsmall cell lung cancer.

Comparisons with the overall prevalence demonstrate that the model is not solely driven by prevalence, as genes with relative high prevalence, such as RASSF1A , which are methylated in approximately 50% of cases, in fact have a nonsignificant and negative item response slope, while CCND2 (encoding Cyclin-D2), with a prevalence of methylation of approximately 30%, has a highly significant slope of 1.3.

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