Multilayered mechanism of CD4 downregulation by HIV-1 Vpu involving distinct ER retention and ERAD targeting steps.

PLoS Pathog · 2010 · PMC2861688 · PMID 20442859

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highly significantno p-value reported

These observations are highly significant because Vpu, unlike mK3, does not have intrinsic Ub ligase activity, indicating that serine/threonine residues could be ubiquitinated by a cellular enzyme.

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