Phylodynamic reconstruction reveals norovirus GII.4 epidemic expansions and their molecular determinants.

Three of the sites (6, 9 and 534) were confirmed by a site-by-site Fixed Effects Likelihood (FEL) analysis at p <0.05, while the remaining two (15 and 47) were borderline significant ( p = 0.06 and p = 0.10).

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The 1996 variant, that was detected in the population during a relatively long period, but at low reporting frequencies after the initial epidemic (winter of 1995–1996, in the northern hemisphere) ( Figure 1A/B ), showed an increasing trend in the N e τ values persisting long after this first peak.

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