Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF.

Furthermore, while V600E BRAF mutations (over 10,000 described) occur in a mutually exclusive manner with RAS mutations, four of the 34 kinase-dead mutants are coincident with RAS mutations, a highly significant enrichment (p < 10 −9 ; Fisher's Exact Test) that suggests functional interaction.

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