Human variation in short regions predisposed to deep evolutionary conservation.

Mol Biol Evol · 2010 · PMC2872621 · PMID 20093432

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highly significantno p-value reported

As an example, the derived G allele of one of the hotSNPs, rs12469063 (16.5% MAF, Fst = 0.14), resides in a deeply conserved region of the MEIS1 intron and is known to have a highly significant association with the restless legs syndrome ( Schimmelmann et al. 2009 ).

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