Genomic features defining exonic variants that modulate splicing.

Genome Biol · 2010 · PMC2872880 · PMID 20158892

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highly significantno p-value reported

Moreover, the highly significant difference in ESS gains between SAVs and hSNPs can be further explained by a significant reduction for this type of change in hSNPs compared to the expected distribution (5.6% of changes in hSNPs versus 8.3% under neutrality, χ 2 test P = 1.7 × 10 -8 ), suggesting negative selection against the gain of silencers in common variants.

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