Despite reciprocal changes in the transcript levels of multiple genes including those associated with TGF-β and IGF-1 signaling pathways over the 2-8 month and 8-26 month periods, there was an overall trend of decreased osteogenic and adipogenic marker expression over the entire 2- to 26-month period of aging.
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Age-related molecular genetic changes of murine bone marrow mesenchymal stem cells.
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