Effects of MDM2, MDM4 and TP53 codon 72 polymorphisms on cancer risk in a cohort study of carriers of TP53 germline mutations.

When including the imputed data, a trend towards significance was noted for the univariable analysis of the MDM2 G allele ( P = 0.0764 unadjusted and P = 0.1067 adjusted analysis) ( Table 2 ), but carriers of a G allele had a 1.58 fold increased risk for cancer after adjusting for sex, race, birth year, and effects from other polymorphisms in multivariable analysis ( P = 0.0313) ( Table 3 ).

also in 2,760 other papers