Effects of lovastatin on breast cancer cells: a proteo-metabonomic study.

In regards to surrogate markers for ROS formation, 1 H-NMR analysis of cell extracts revealed a highly significant decline in total cellular glutathione concentrations (from 2595 ± 168 nmol/g in controls to 871 ± 72 and 1149 ± 78 nmol/g in lovastatin lactone and acid treated cells; P < 0.001, n = 3, Table 2 and Figure 6 ), suggesting an increase in oxidative damage.

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