Effects of childhood body size on breast cancer tumour characteristics.

After adjustment of known breast cancer predictors and other associated risk factors, the inverse association of somatotype at age seven years with breast cancer remained highly significant (Table 2 ; OR comparing large to lean somatotype at age seven years = 0.73, 95% CI = 0.58 to 0.91, P trend = 0.004).

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The protective effect of a larger somatotype was found to be significant ( P trend < 0.05) for ER-negative, PR-positive and PR-negative subtypes and marginally significant ( P trend = 0.062) for the ER-positive subtype.

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