Prostaglandin E 2 production was statistically and significantly increased in primary EM cultures from 4 of 10 donors (M20, 24, 29 and 45) with a positive trend in a further two cultures (23 and 40) 24 h after 73 mJ/cm 2 UVB ( Figure 4A ).
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Prostaglandin-E2 is produced by adult human epidermal melanocytes in response to UVB in a melanogenesis-independent manner.
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