The spontaneous transfer of ceramide may be significant as it is unclear whether ceramides are completely degraded by acid ceramidase or, in part, can leave the acidic compartments intact as shown previously for endocytosed, nondegradable analogs of glucosylceramide and gangliosides GM2 and GM1 ( 74 – 77 ).
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Role of endosomal membrane lipids and NPC2 in cholesterol transfer and membrane fusion.
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