The early nutritional environment of mice determines the capacity for adipose tissue expansion by modulating genes of caveolae structure.

A model based upon dietary manipulations of the lactating mother Using pooled data from Control, LON and LUN groups of Cohort II, we show a highly significant correlation between fat mass at 10 days of age and 112 days of age ( Figure 6A R = 0.63), suggesting that 40% of the variance in adiposity at 10 days of age is associated with adiposity at 112 days of age after being fed a high fat diet for 8 weeks.

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Despite the obvious requirement for transcriptional mechanisms to modulate the changes in mRNA levels for these genes of the cytoskeleton, no unifying pattern in the expression profiles of the major genes encoding transcription factors of adipogenesis was observed (Supplemental Figure S1 ) and the correlation coefficients of PPARγ with fat mass at 10 and 112 days of age were non-significant (R = −0.01 and 0.14, respectively) and showed only marginal significance with some of the genes of ATE ( Figure 6 ).

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