Assessment of distinct angiogenic factors showed that VEGF was the only angiogenic factor that displayed a diabetes-specific distribution, although TNF-α showed the same profile but did not achieve significance.
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Profile of lipid and protein autacoids in diabetic vitreous correlates with the progression of diabetic retinopathy.
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The sentences
In line with these characteristics, the finding of high levels of 5-HETE in the diabetic vitreous is highly significant. 5-HETE is generally devoid of the powerful inflammatory properties of LTs; however, its presence indicates a considerable 5-LO activity as it is the degradation product of 5-HPETE, the unstable intermediate in the synthesis of LTA 4 and consequently cysteinyl-LTs ( 21 ).