Deconvoluting lung evolution: from phenotypes to gene regulatory networks.

Integr Comp Biol · 2007 · PMC2895359 · PMID 20607138

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highly significantno p-value reported

In addition, PTHrP signaling from the epithelium to the mesoderm is highly significant—it is the earliest known developmental signal emanating from the endoderm, perhaps reflecting its atavistic, evolutionary relationship to the swim bladder as an adaptation to gravity (Torday 2003 ).

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