Barely Significant
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Combinatorial binding leads to diverse regulatory responses: Lmd is a tissue-specific modulator of Mef2 activity.

PLoS Genet · 2010 · PMC2895655 · PMID 20617173

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hedged sentence
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The sentences

highly significantp <2.2×10 −16actually significant
Comparing these data to that of Lmd revealed that a large (79.7%) and highly significant ( p <2.2×10 −16 , Fisher's exact test) proportion of Lmd direct target genes are also directly regulated by Mef2 ( Figure 1D ).

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