Random associations can make a SNP highly significant by chance, and can be more problematic in a quantitative trait study where GWA analysis softwares such as PLINK apply a linear regression to approximate the significance of each SNP.
1
—
—
Random associations can make a SNP highly significant by chance, and can be more problematic in a quantitative trait study where GWA analysis softwares such as PLINK apply a linear regression to approximate the significance of each SNP.