Benzene exposure near the U.S. permissible limit is associated with sperm aneuploidy.

Environ Health Perspect · 2010 · PMC2898861 · PMID 20418200

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Our findings predict that occupational benzene exposures may significantly increase the risks of pregnancies with triple X and XYY syndromes, with lower and only borderline significant predicted risks for offspring with Klinefelter syndrome (XY sperm, IRR = 1.5 and 1.8 for low-exposed and high-exposed, respectively) and Down syndrome (sperm disomy 21, IRR = 2.1 and 1.6 for low-exposed and high-exposed, respectively).

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