A53T-alpha-synuclein overexpression impairs dopamine signaling and striatal synaptic plasticity in old mice.

However, a highly significant decrease of the transcript levels of the DA degradation enzyme COMT was observed in both A53T-SNCA overexpressing mouse lines ( Fig. 3 ; PrPmtA: −30%, n = 6, p = 0.0005 and PrPmtB: −26%, n = 7, p = 0.0018).

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