Partial loss of ataxin-1 function contributes to transcriptional dysregulation in spinocerebellar ataxia type 1 pathogenesis.

PLoS Genet · 2010 · PMC2900305 · PMID 20628574

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closest p · 0.0× alpha

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boldest claim

The sentences

highly significantP -value<2.2e-16actually significant

We observed a highly significant rate of concordance and overlap between cerebellar expression profiles of Atxn1 −/− and Atxn1 154Q /+ mice (z = 11.9485, P -value<2.2e-16, Kendall-τ test).

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a small trendno p-value reported

Atxn1 −/− mice (n = 10) and wild-type controls (n = 9) were tested at 12 weeks of age (A) Atxn1 −/− mice had a small trend to spend more time in the light side than wild-type controls, although this trend does not reach significance (p = 0.26).

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