Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole.

There was, however, a numerically highly significant tendency ( P < 0.0001 by Mann–Whitney test) towards reduced Irgb6 vacuole loading intensity in Irga6-deficient cells relative to the wild-type (wt) cells ( Fig. 6F ), suggesting that the presence of Irga6 may stabilize the loading of Irgb6.

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In this context, it may be significant that both Irgb6 and Irgb10 can load, albeit inefficiently, onto T. gondii vacuoles in the absence of other IRG proteins ( Hunn et al. , 2008 , Fig. 7 and J.P.

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