Although, these hits had only marginal significance, they perfectly aligned with the three principal acidic catalytic residues of the diguanylate cyclases/GGDEF domain (Fig. 1 ).
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Presence of a classical RRM-fold palm domain in Thg1-type 3'- 5'nucleic acid polymerases and the origin of the GGDEF and CRISPR polymerase domains.
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