Pretreatment with statins improves early outcome in patients with first-ever ischaemic stroke: a pleiotropic effect of statins or a beneficial effect of hypercholesterolemia?

As shown in Table 3 , the frequency of favourable outcome and in-hospital mortality in relation to the use of statins when the study period was divided into three periods (1986-1992; 1993-1998; 1999-2004) did not show significant differences, although a decreasing trend in the mortality rate was observed.

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The proportion of patients with neurological complications was also lower in the statin-treated group and almost reached statistical significance.

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