Small study effects in meta-analyses of osteoarthritis trials: meta-epidemiological study.

36 38 41 43 44 The regression test was significant at P≤0.05 in four meta-analyses (D, G, H, M) 16 37 39 42 and showed a statistical trend in another two (P≤0.10, A, L). 44 45 In five funnel plots, the contours to distinguish between areas of significance and non-significance at P=0.05 suggested missing trials in areas of non-significance (A, C, D, H, L). 16 42 44 45 46 The weighted average of asymmetry coefficients across all meta-analyses was −1.79 (−2.81 to −0.78).

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