A study conducted to determine the gonadotoxic effect of sodium valproate found that serum testosterone levels were not significantly changed, but there was a highly significant increase in FSH and LH concentrations at the high dose.[ 14 ] However, an earlier study by Soliman et al [ 5 ] had reported a decrease in plasma testosterone, FSH and LH and an increase in prolactin levels on treatment with sodium valproate.
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