Barely Significant
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The BRCT domain of PARP-1 is required for immunoglobulin gene conversion.

PLoS Biol · 2010 · PMC2907289 · PMID 20652015

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The sentences

highly significantp <.0001actually significant
In these additional analyses, the difference in GCV frequencies between WT and PARP−/− cells at the IgL locus remains highly significant ( p <.0001 and p = .0006, respectively), although the number of mutations scored at the less well defined IgH locus was not sufficient to reveal a significant difference in these more conservative analyses ( p = .1023 and p = .1280, respectively).

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