When treated mice were plotted according to age, blood glucose at the time of treatment and progression to diabetes, an interesting trend emerged, namely that the earlier the disease manifestation and the higher the blood glucose, the more difficult it was to reverse hyperglycaemia (Fig. 1d ).
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Subcutaneous insulin B:9-23/IFA immunisation induces Tregs that control late-stage prediabetes in NOD mice through IL-10 and IFNgamma.
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