PERK (EIF2AK3) regulates proinsulin trafficking and quality control in the secretory pathway.

We also found a highly significant 3.6-fold increase in the accumulation of Ins + -KDEL in the PERK-suppressed cells compared with the empty-vector cotransfected controls ( Fig. 5 D ), while proinsulin and steady-state protein synthesis levels in these cells showed no significant changes ( Fig. 1 H–I ; supplementary Fig.

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