Detection and analysis of alternative splicing in Yarrowia lipolytica reveal structural constraints facilitating nonsense-mediated decay of intron-retaining transcripts.

First, as previously reported for various eukaryotes [ 63 , 64 ] most introns were inserted in phase 0 (40.2% of all introns) or phase 1 (38%), with a highly significant underrepresentation of intron insertions in phase 2 (21.8%; c 2 = 64.68, P = 8.98e -15 ; Figure 2a ).

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