Transcriptomic epidemiology of smoking: the effect of smoking on gene expression in lymphocytes.

There were several highly significant functional categories involved in various aspects of cell death, including 17 genes involved in cell cytotoxicity ( CD38 , CD300A , FASLG , FCGR3A , FCGR3B , GZMA , GZMB , KLRB1 , KLRD1 , KLRF1 , KLRK1 , PRF1 , PTGDR , PTPN6 , SLAMF7 , SPN , TNFRSF8 ; p = 3.7 × 10 -10 ) and 11 in cell lysis ( ABCB1 , CX3CR1 , FASLG , FCGR3A , GNLY , GZMA , GZMB , KLRB1 , KLRD1 , KLRK1 , PRF1 ; p = 1.2 × 10 -7 ) that were all significantly negatively correlated with smoking.

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