Global coordination of transcriptional control and mRNA decay during cellular differentiation.

We carried out two additional experiments to confirm the specificity of the RIp-chip results: first, we analysed the results of a Meu5p immunoprecipitation experiment using a different microarray platform (see Materials and methods), and observed an extensive and highly significant overlap between the transcripts identified with both systems ( Supplementary Figure S3 ; P -value 4 × 10 −109 ).

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