Here we present evidence that treatment of a human patient with ovarian carcinoma using the DTA-H19 construct leads to a highly significant suppression of ascites progression with very limited apparent toxicity toward the host, indicating that these constructs have a high therapeutic potential and are very promising candidates for ovarian cancer therapy in humans.
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Treatment of ovarian cancer ascites by intra-peritoneal injection of diphtheria toxin A chain-H19 vector: a case report.
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