Paralysis and delayed Z-disc formation in the Xenopus tropicalis unc45b mutant dicky ticker.

BMC Dev Biol · 2010 · PMC2919470 · PMID 20637071

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closest p · 0.2× alpha

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highly significantp < 0.01actually significant

Both a translation blocking (ATG-MO) and a splice blocking AMO deleting ~2/3 of the mature protein (Splice-MO) resulted in highly significant numbers of paralysed or partially paralysed tadpoles lacking heartbeat (ATG-MO 42/49 (p < 0.01); Splice-MO 32/34 (P < 0.01), compared to 0/52 in control AMO-injected embryos).

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