5-Fluorouracil response in a large panel of colorectal cancer cell lines is associated with mismatch repair deficiency.

Mutations in TGFbIIR, which are nearly always found in microsatellite unstable tumours because of a coding mononucleotide repeat in the TGFbIIR gene ( Markowitz et al , 1995 ; Samowitz et al , 2002 ), are on the margin of significance, with P =0.035.

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