Initially, we modeled each gene promoter individually, and observed significant associations between FRZB (OR 2.9, 95% CI 1.1, 7.9), and KRT13 (OR 3.3, 95% CI 1.1, 10.1), but only a borderline significant association between HOXB2 methylation and high tumor grade (OR 2.6, 95% CI 0.9, 6.9, Table S2 ).
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Identification of methylated genes associated with aggressive bladder cancer.
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