The identification of a cell contact-dependent program that drives the initial stages of hippocampal synaptogenesis may be significant not only for understanding neuronal maturation mechanisms, but also for devising therapies for treatment of neuron migration diseases, and for the preparation of stem cells for injection into hippocampus during restorative stem cell therapy.
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Ephrin-A5 and EphA5 interaction induces synaptogenesis during early hippocampal development.
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