HPK1 associates with SKAP-HOM to negatively regulate Rap1-mediated B-lymphocyte adhesion.

Wortmannin (100 μM) and U73122 (1 μM) treated co and kd cells showed a highly significant difference (WM co: 8.54%±1.72%; kd: 27.52%±1.95%; U73122 co: 5.91%±1.31%; kd: 34.66%±4.46%) in adhesion as observed for DMSO controls (co: 18.18%±1.76%; kd: 47.72%±2.15%), suggesting that although PLCγ2 and PI3K contribute to overall adhesion, they are not causative for the observed increase in LFA-1 activity.

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