highly significantP < 0.001
In a naturalistic study of 53 patients with psychotic disorders prescribed sertindole (8–24 mg/d) before its withdrawal from the market, improvement in global assessment of functioning (GAF) and CGI scores between admission and discharge was highly significant ( P < 0.001). 80 Another smaller observational study of 34 patients with psychotic disorders reported an 85% response rate (defined as achieving a CGI score ≤ 3) with sertindole use initiated in the inpatient setting. 42 In summary, both real-world and clinical research data support the efficacy of sertindole in the treatment of patients with schizophrenia (and to a lesser extent other psychotic disorders), although current evidence for its efficacy is limited to comparisons with placebo, haloperidol, and risperidone.