Colonic biopsies to assess the neuropathology of Parkinson's disease and its relationship with symptoms.

When PS+ patients were further stratified into subgroups with moderate (+) and severe (++) pathology, there was a highly significant difference in NF-IR between PS+ patients with severe pathology (++) and the control group (p<0.01), and furthermore significant differences were apparent between the severe pathology group and those with absent (0) and moderate (+) pathology (p<0.05) ( figure 2D ).

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