Effect of ABCB1 C3435T polymorphism on docetaxel pharmacokinetics according to menopausal status in breast cancer patients.

Br J Cancer · 2010 · PMC2939787 · PMID 20628376

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highly significantno p-value reported

Results: A highly significant association was observed, but restricted to premenopausal women ( n =53), between the pharmacokinetics of docetaxel and C3435T polymorphism, as patients with CC genotype had lower mean values of the area under the plasma concentration-time curve (AUC) of docetaxel than patients with CT and TT genotypes ( P <0.0001).

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