Relative contributions of intrinsic structural-functional constraints and translation rate to the evolution of protein-coding genes.

For each lineage, a moderate but highly significant negative correlation was observed between the ER and protein abundance ( fig. 1 C and 1 D ), in agreement with the universal negative correlation between ER and expression level ( Pal et al. 2001 ; Krylov et al. 2003 ; Wolf et al. 2006 ; Drummond and Wilke 2008 , 2009 ).

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